Allostatic load is the cumulative burden on your body and brain when they are constantly trying to adapt to stress. It’s like your body’s “wear and tear” from repeatedly being in a state of heightened alertness or stress.
If this load becomes too great, it can trigger protective responses like the cellular danger response (CDR).
Trauma
Grief
Burnout
Allostatic Load
CDR Activation
Autoimmunity
Neuroinflammation
Neurodegeneration
The CDR impacts numerous cellular functions which are ultimately fueled by nutrients, that temporarily changes how your cells work to keep you safe.
If the CDR is activated for long periods of time, especially without nutrition to support recovery, it can lead to a variety of neuropsychological changes and challenges that often accompany or preface chronic health conditions.
Chronic CDR Activation
Brain Region Volume
Oxidative Stress
Neuroinflammation
Blood-Brain Barrier Permeability
Cholesterol Depletion
Neurogenesis
Nutrient Demand
Gut-Brain Axis Dysfunction
Cytokine Production
Cellular Apoptosis
HPA-Axis Dysfunction
Immune Function
Excitotoxicity
Mitochondrial Dysfunction
Methylation
Blood Sugar Metabolism Impairment
Synaptic Protein Density
Hyperarousal
Hypervigilance
Executive Function
Pain Intensity
Irritability
Mood Swings
Memory
Headaches
Sleep Disturbances
Because of the abnormally upregulated (fast-paced) activity in your cells resulting from the CDR, your brain and body will utilize more vitamins, minerals, amino acids and macronutrients than normal. This can have a number of neuropsychological consequences that might make it challenging to build consistent routines, stay focused, think clearly, and have the capacity to participate in other healing and recovery experiences like therapy, meditation, exercise and co-regulationwith your community.
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Neuronutrition is an interdisciplinary field that integrates theories, practices, and research from neuroscience (including behavioral, social, and nutritional neuroscience), nutrition science (specifically personalized and precision nutrition and nutrigenomics), and neuropsychology.
Neuronutrition examines how nutrients, dietary supplements, food additives, and the social and environmental contexts of eating influence neurochemistry, neurobiology, behavior, and cognition.
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